What are goji berries?

The plant Lycium barbarum has berries (goji) that have been used in Traditional Chinese medicine for over 2000 years (1,2). The plant’s berries are sweet and tangy and have an orangeish red color. They are native to Asia, especially regions of China. They are also found in Japan, Korea, and Taiwan. They are usually found as dried berries in the grocery store. Goji berries are recognized as a superfruit with anti-aging and antioxidant properties (3). They are traditionally used in tea, soups, Asian cuisine, and in combination with meat and vegetables in meals. They can also be used for the production of wines or juices. In traditional Chinese medicine, they have the ability to maintain eye function, tonic the liver, nourish the kidney and lungs by balancing Yin and Yang in the body (1,2).

What are the features of goji berries?

Today, goji berries are considered a superfruit because of their nutrients and highly active composition including sugar or polysaccharide complexes, carotenoids, and phenylpropanoids to name a few (4). The most important of these is the polysaccharide complexes termed L. barbarum polysaccharides (LBP). These complexes include the monosaccharides arabinose, rhamnose, xylose, mannose, galactose, glucose along with galacturonic acid and 18 amino acids (5,6). The second most abundant active component are the carotenoids. They give the berries their orange-red color. The phenylpropanoids give goji berries their very high antioxidant ability. Goji berries also have vitamins such as thiamin, riboflavin and ascorbic acid.

What are the health benefits of Goji berries?

LBP exhibit a wide range of therapeutic benefits for aging, fatigue, cancer, colitis, stroke, diabetes, Alzheimer’s disease and glaucoma in animal models (7). The antioxidant activity in goji berries reduce oxidative stress-induced damage in cells and this benefit can be seen in a number of conditions.

Healthy people

In a study with healthy volunteers, it was found that the juice increased energy levels, athletic performance, quality of sleep, ability to focus, mental acuity, happiness, reduced fatigue and stress and improved gastrointestinal function (8). Another study found that the juice improved strength, stress, mental acuity, ease of awakening, shortness of breath, focus, sleep quality, daydreaming and overall health (9).

Cancer

Cancer cells are mutated such that they do not grow properly in addition to other dysregulated processes. LBPs are a safe option that reduces the cancer effects in the body and in the lab (10). They could even be used to reduce the side effects of other cancer therapies. (10). LBP inhibited the growth of breast cancer cells, cervical cancer cells, human colon cancer cells, leukemia cells and hepatoma cells in the lab (11-15). LBP inhibited sarcoma growth in mice and enhanced immune activities (16). LBP also reduced the size of the tumor in a prostate cancer mouse model (17). In addition, when advanced cancer patients were treated with an immunity treatment in combination with LBPs, it was found that the treatment was more effective with LBPs (18). LBPs also increased their immune cell activity (18).

Anti-aging

As we age, our immune systems’ responsiveness decreases and there are functional irregularities which lead to a poor overall immune health against pathogens and an increased response against self (19). Oxidative damage also increases with age (20,21). Antioxidants such as those found in goji berries play a major role in slowing down the aging process. In a study on an aging Chinese population, it was found that it increased immune cell counts, reduced fatigue and improved mental ability (22). Another study found that consuming it for 3 months with the influenza vaccine showed that they had better immunity against the virus (23). Goji berries reduce oxidative stress in the aging population, protecting them from some harmful effects of aging (24).

Weight loss

Goji berries were found to reduce caloric expenditure and reduce waist circumference in overweight individuals (25). LBPs also have a hypolipidemic effect in animals (26).

Eyes and glaucoma

LBPs have shown protective effects against certain retinal injuries and have a protective effect in animal models (27-35). LBPs may be a potential treatment for vascular-related retinopathy (29). They are also therapeutic against neurodegeneration in the retina in a rat model (32) Through the reduction of oxidative stress, LBPs are able to promote the survival of photoreceptors (35).

Liver and hepatoprotective effects

LBPs can reverse alcohol-induced liver damages and prevent the progression of fatty liver disease in rats (36). LBPs are able to reduce oxidative stress, reduce the inflammatory response and protect the liver from various injuries in animals (reviewed in 7).

Diabetes

Studies in animals have shown that LBPs can lower glucose levels and increase insulin sensitivity by increasing antioxidation, glucose metabolism, and insulin secretion (37-43).

Immunomodulating effects

LBPs have immuno-enhancement functions (44-46). They improve responsiveness in aging models (47). They enhance B cell, T cell and macrophage functions (reviewed in 7). LBP also stimulate moderate immune responses, and therefore, can potentially be used an adjuvant in vaccines (48).

Brain effects

LBPs possess neuroprotective effects (49-51) but the mechanisms have not yet been fully elucidated. In animals, LBPs can protect against neuronal injury or loss induced neurotoxic insults (52-55). LBPs may also enhance neurogenesis (56,57). LBPs have a neuroprotective effect when there is a risk of Alzheimer’s disease in animal models (58).

Removing toxicities

LBPs promote blood and bone marrow recovery from irradiation or chemotherapy-induced damage in mice (59).

Reproductive system

Goji berries are described to have a pro-sexual effect and thus it is included in sexual-enhancing Chinese herbal remedies. Daily consumption of goji juice in healthy people improves sexual well-being and can increase sexual activity and ability (24). LPBs protect the reproductive system through antioxidation and promotion of cell proliferation.

Other Effects

Chronic fatigue syndrome is a complicated condition with persistent tiredness, impaired memory, sore throat, tender lymph nodes, muscle pain, joint pain, headaches, unrefreshing sleep. LBPs enhanced elimination of fatigue (60). Some LBPs also have antiviral activity (61) LBPs also have a cardioprotective effect through their antioxidative and anti-inflammatory activity (62) 

Precautions

A better understanding is needed of goji berries in regard to their affected pathways and therapeutic targets. There are no reports on the severe toxicity of LBPs in humans. But there are possible interactions between warfarin and LBPs, indicating a potential risk of goji–warfarin interaction. Clinical safety data on LBPs are sparse. 

MapleLife Goji Berry Juice

MapleLife is a well-reputed company for making quality supplements. In a number of the studies listed here, goji juice was used with clinical patients. MapleLife has used goji berries from Ningxia, China to make a 100% pure goji berry juice available for consumption. The versatility of this is amazing because you get the benefit of the berries that you can use in cocktails, juice blends, healthy shakes, or any way you prefer to consume it. Considering the many benefits of Goji berries listed here, they should be an important part of your diet.

References

1. Potterat O. Goji (Lycium barbarum and L. chinense): phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Med. 2010;76(1):7–19.
2. Chang RC, So KF. Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far? Cell Mol Neurobiol. 2008;28(5):643–652.
3. Ulbricht C, Bryan JK, Costa D, et al. An evidence-based systematic review of Goji (Lyciumspp.) by the Natural Standard Research Collaboration. J Diet Suppl. 2014 May 7; Epub.
4. Toyoda-Ono Y, Maeda M, Nakao M, Yoshimura M, Sugiura-Tomimori N, Fukami H. 2-O-(β-D-glucopyranosyl)ascorbic acid, a novel ascorbic acid analogue isolated from Lycium fruit. J Agric Food Chem. 2004;52(7):2092–2096
5. Huang LJ, Tian GY, Ji GZ. Structure elucidation of glycan of glycocon-jugate LbGp3 isolated from the fruit of Lycium barbarum L. J Asian Nat Prod Res. 1999;1(4):259–267.
6. Peng X, Tian G. Structural characterization of the glycan part of glycoconjugate LbGp2 from Lycium barbarum L. Carbohydr Res. 2001;331(1):95–99
7. Cheng, J., Zhou, Z.-W., Sheng, H.-P., He, L.-J., Fan, X.-W., He, Z.-X., … Zhou, S.-F. (2015). An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides. Drug Design, Development and Therapy, 9, 33–78. https://doi.org/10.2147/DDDT.S72892
8. Amagase H, Nance DM. A randomized, double-blind, placebo-controlled, clinical study of the general effects of a standardized Lycium barbarum (Goji) Juice, GoChi. J Altern Complement Med. 2008;14(4):403–412.
9. Paul Hsu CH, Nance DM, Amagase H. A meta-analysis of clinical improvements of general well-being by a standardized Lycium barba-rum. J Med Food. 2012;15(11):1006–1014.
10. Tang WM, Chan E, Kwok CY, et al. A review of the anticancer and immunomodulatory effects of Lycium barbarum fruit. Inflammopharmacology. 2012;20(6):307–314.
11. Li G, Sepkovic DW, Bradlow HL, Telang NT, Wong GY. Lycium barbarum inhibits growth of estrogen receptor positive human breast cancer cells by favorably altering estradiol metabolism. Nutr Cancer. 2009;61(3):408–414.
12. Hu Q, Gao T, Zhao C, et al. The effect of active components of Lycium barbarum and garlic (LB-GO) on the synthesis of DNA and ultrastructure of u14 cervix cancer cells in mice. Chin J Cancer Res. 1994;6(4):266–273.
13. Mao F, Xiao B, Jiang Z, Zhao J, Huang X, Guo J. Anticancer effect of Lycium barbarum polysaccharides on colon cancer cells involves G0/G1 phase arrest. Med Oncol. 2011;28(1):121–126.
14. Gan L, Wang J, Zhang S. Inhibition the growth of human leukemia cells by Lycium barbarum polysaccharide. Wei Sheng Yan Jiu. 2001;30(6):333–335. Chinese.
15. Zhang M, Chen H, Huang J, Li Z, Zhu C, Zhang S. Effect of Lycium barbarum polysaccharide on human hepatoma QGY7703 cells: inhibition of proliferation and induction of apoptosis. Life Sci. 2005;76(18):2115–2124.
16. Gan L, Hua Zhang S, Liang Yang X, Bi Xu H. Immunomodulation and antitumor activity by a polysaccharide-protein complex from Lycium barbarum. Int Immunopharmacol. 2004;4(4):563–569.
17. Luo Q, Li Z, Yan J, Zhu F, Xu RJ, Cai YZ. Lycium barbarum polysaccharides induce apoptosis in human prostate cancer cells and inhibits prostate cancer growth in a xenograft mouse model of human prostate cancer. J Med Food. 2009;12(4):695–703.
18. Cao GW, Yang WG, Du P. Observation of the effects of LAK/IL-2 therapy combining with Lycium barbarum polysaccharides in the treatment of 75 cancer patients. Zhonghua Zhong Liu Za Zhi. 1994;16(6):428–431. Chinese.
19. Fulop T, Le Page A, Fortin C, Witkowski JM, Dupuis G, Larbi A. Cellular signaling in the aging immune system. Curr Opin Immunol. 2014;29C:105–111.
20. Long YC, Tan TM, Takao I, Tang BL. The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signaling. Am J Physiol Endocrinol Metab. 2014;306(6):E581–E591.[PubMed]
21. Dai DF, Chiao YA, Marcinek DJ, Szeto HH, Rabinovitch PS. Mitochondrial oxidative stress in aging and healthspan. Longev Healthspan. 2014;3:6
22. Amagase H, Sun B, Nance DM. Immunomodulatory effects of a standardized Lycium barbarum fruit juice in Chinese older healthy human subjects. J Med Food. 2009;12(5):1159–1165.
23. Vidal K, Bucheli P, Gao Q, et al. Immunomodulatory effects of dietary supplementation with a milk-based wolfberry formulation in healthy elderly: a randomized, double-blind, placebo-controlled trial. Rejuvenation Res. 2012;15(1):89–97.
24. Amagase H, Sun B, Borek C. Lycium barbarum (goji) juice improves in vivo antioxidant biomarkers in serum of healthy adults. Nutr Res. 2009;29(1):19–25.
25. Amagase H, Nance DM. Lycium barbarum increases caloric expenditure and decreases waist circumference in healthy overweight men and women: pilot study. J Am Coll Nutr. 2011;30(5):304–309.
26. Luo Q, Cai Y, Yan J, Sun M, Corke H. Hypoglycemic and hypolipi-demic effects and antioxidant activity of fruit extracts from Lycium barbarum. Life Sci. 2004;76(2):137–149.
27. Li SY, Yang D, Yeung CM, et al. Lycium barbarum polysaccharides reduce neuronal damage, blood–retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injury. PLoS One. 2011;6(1):e16380. [PMC free article] [PubMed]
28. He M, Pan H, Chang RC, So KF, Brecha NC, Pu M. Activation of the Nrf2/HO-1 antioxidant pathway contributes to the protective effects of Lycium barbarum polysaccharides in the rodent retina after ischemia-reperfusion-induced damage. PLoS One. 2014;9(1):e84800. [PMC free article] [PubMed]
29. Mi XS, Feng Q, Lo AC, et al. Protection of retinal ganglion cells and retinal vasculature by Lycium barbarum polysaccharides in a mouse model of acute ocular hypertension. PLoS One. 2012;7(10):e45469.[PMC free article] [PubMed]
30. Li H, Liang Y, Chiu K, et al. Lycium barbarum (wolfberry) reduces secondary degeneration and oxidative stress, and inhibits JNK pathway in retina after partial optic nerve transection. PLoS One. 2013;8(7):e68881. [PMC free article] [PubMed]
31. Chu PH, Li HY, Chin MP, So KF, Chan HH. Effect of Lycium barbarum (wolfberry) polysaccharides on preserving retinal function after partial optic nerve transection. PLoS One. 2013;8(12):e81339.[PMC free article] [PubMed]
32. Chan HC, Chang RC, Koon-Ching Ip A, et al. Neuroprotective effects of Lycium barbarum Lynn on protecting retinal ganglion cells in an ocular hypertension model of glaucoma. Exp Neurol. 2007;203(1):269–273. [PubMed]
33. Chiu K, Chan HC, Yeung SC, et al. Modulation of microglia by Wolf-berry on the survival of retinal ganglion cells in a rat ocular hypertension model. J Ocul Biol Dis Infor. 2009;2(2):47–56.[PMC free article] [PubMed]
34. Chiu K, Zhou Y, Yeung SC, et al. Up-regulation of crystallins is involved in the neuroprotective effect of wolfberry on survival of retinal ganglion cells in rat ocular hypertension model. J Cell Biochem. 2010;110(2):311–320. [PubMed]
35. Miranda M, Arnal E, Ahuja S, et al. Antioxidants rescue photoreceptors in rd1 mice: relationship with thiol metabolism. Free Radic Biol Med. 2010;48(2):216–222.
36. Cheng D, Kong H. The effect of Lycium barbarum polysaccha-ride on alcohol-induced oxidative stress in rats. Molecules. 2011;16(3):2542–2550.
37. Li XM. Protective effect of Lycium barbarum polysaccharides on streptozotocin-induced oxidative stress in rats. Int J Biol Macromol. 2007;40(5):461–465.
38. Zhu J, Liu W, Yu J, et al. Characterization and hypoglycemic effect of a polysaccharide extracted from the fruit of Lycium barbarum L. Carbohydr Polym. 2013;98(1):8–16. [PubMed]
39. Wu H, Guo H, Zhao R. Effect of Lycium barbarum polysaccharide on the improvement of antioxidant ability and DNA damage in NIDDM rats. Yakugaku Zasshi. 2006;126(5):365–371. [PubMed]
40. Luo Q, Cai Y, Yan J, Sun M, Corke H. Hypoglycemic and hypolipi-demic effects and antioxidant activity of fruit extracts from Lycium barbarum. Life Sci. 2004;76(2):137–149. [PubMed]
41. Zhao R, Li Q, Xiao B. Effect of Lycium barbarum polysaccharide on the improvement of insulin resistance in NIDDM rats. Yakugaku Zasshi. 2005;125(12):981–988. [PubMed]
42. Zhao R, Qiu B, Li Q, et al. LBP-4a improves insulin resistance via translocation and activation of GLUT4 in OLETF rats. Food Funct. 2014;5(4):811–820. [PubMed]
43. Yang Y, Li W, Li Y, Wang Q, Gao L, Zhao J. Dietary Lycium barbarum polysaccharide induces Nrf2/ARE pathway and ameliorates insulin resistance induced by high-fat via activation of PI3K/AKT signaling. Oxid Med Cell Longev. 2014;2014:145641.
44. Chen Z, Kwong Huat Tan B, Chan SH. Activation of T lymphocytes by polysaccharide-protein complex from Lycium barbarum L. Int Immunopharmacol. 2008;8(12):1663–1671. [PubMed]
45. Macian F. NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol. 2005;5(6):472–484. [PubMed]
46. Waldmann TA. The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nat Rev Immunol. 2006;6(8):595–601.
47. Vidal K, Benyacoub J, Sanchez-Garcia J, et al. Intake of a milk-based wolfberry formulation enhances the immune response of young-adult and aged mice. Rejuvenation Res. 2010;13(1):47–53.
48. Du X, Wang J, Niu X, Smith D, Wu D, Meydani SN. Dietary wolfberry supplementation enhances the protective effect of flu vaccine against influenza challenge in aged mice. J Nutr. 2014;144(2):224–229.
49. Zhang YK, Wang J, Liu L, Chang RC, So KF, Ju G. The effect of Lycium barbarum on spinal cord injury, particularly its relationship with M1 and M2 macrophage in rats. BMC Complement Altern Med. 2013;13:67. [PMC free article] [PubMed]
50. Rui C, Yuxiang L, Yinju H, et al. Protective effects of Lycium barbarum polysaccharide on neonatal rat primary cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion. J Mol Histol. 2012;43(5):535–542. [PubMed]
51. Chen W, Cheng X, Chen J, et al. Lycium barbarum polysaccharides prevent memory and neurogenesis impairments in scopolamine-treated rats. PLoS One. 2014;9(2):e88076.
52. Yang D, Li SY, Yeung CM, et al. Lycium barbarum extracts protect the brain from blood–brain barrier disruption and cerebral edema in experimental stroke. PLoS One. 2012;7(3):e33596. [PMC free article][PubMed]
53. Wang T, Li Y, Wang Y, et al. Lycium barbarum polysaccharide prevents focal cerebral ischemic injury by inhibiting neuronal apoptosis in mice. PLoS One. 2014;9(3):e90780. [PMC free article] [PubMed]
54. Yu MS, Leung SK, Lai SW, et al. Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against b-amyloid peptide neurotoxicity. Exp Gerontol. 2005;40(8–9):716–727. [PubMed]
55. Yu MS, Lai CS, Ho YS, et al. Characterization of the effects of anti-aging medicine Fructus lycii on β-amyloid peptide neurotoxicity. Int J Mol Med. 2007;20(2):261–268.
56. Chen W, Cheng X, Chen J, et al. Lycium barbarum polysaccharides prevent memory and neurogenesis impairments in scopolamine-treated rats. PLoS One. 2014;9(2):e88076.
57. Lau BW, Lee JC, Li Y, et al. Polysaccharides from wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis. PLoS One. 2012;7(4):e33374.
58. Ho YS, Yu MS, Yang XF, So KF, Yuen WH, Chang RC. Neuroprotec-tive effects of polysaccharides from wolfberry, the fruits of Lycium barbarum, against homocysteine-induced toxicity in rat cortical neurons. J Alzheimers Dis. 2010;19(3):813–827.
59. Gong H, Shen P, Jin L, Xing C, Tang F. Therapeutic effects of Lycium barbarum polysaccharide (LBP) on irradiation or chemotherapy-induced myelosuppressive mice. Cancer Biother Radiopharm. 2005;20(2):155–162.
60. Luo Q, Yan J, Zhang S. Isolation and purification of Lycium barba-rum polysaccharides and its antifatigue effect. Wei Sheng Yan Jiu. 2000;29(2):115–117. Chinese.
61. Wang J, Hu Y, Wang D, et al. Lycium barbarum polysaccharide inhibits the infectivity of Newcastle disease virus to chicken embryo fibroblast. Int J Biol Macromol. 2010;46(2):212–216.
62. Lu SP, Zhao PT. Chemical characterization of Lycium barbarum polysaccharides and their reducing myocardial injury in ischemia/reperfusion of rat heart. Int J Biol Macromol. 2010;47(5):681–684.